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a study of things as they relate to me. katherinepedia.wordpress.com
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Susie’s Lake, Nova Scotia
  • God: you have to die so their sins can be forgiven
  • Jesus:
  • Jesus:
  • Jesus:
  • Jesus: i just came here to have a good time and i'm honestly feeling so attacked right now
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hellaperfectminho:

amytao297:


agentrodgers:

lady-comedian:

agentrodgers:

fandoms-will-be-the-death-of-me:

agentrodgers:

Just got back from the gym

ARE YOU THE BLACK WIDOW?

……

Barton, I’ve been compromised.


OMG I CAN IMAGINE BARTON ALL LIKE “I TOLD YOU NOT TO GET A TUMBLR!!!”



#SWAGTASHA BROMANOFF


Omg? It got BETTER!
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rachelpuncan:

sleepy-running:

I came out to attack people and I’m honestly having such a good time right now

image

(Source: sleep-ran, via thewetcloud)

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neurosciencestuff:

New study discovers biological basis for magic mushroom ‘mind expansion’
Psychedelic drugs such as LSD and magic mushrooms can profoundly alter the way we experience the world but little is known about what physically happens in the brain. New research, published in Human Brain Mapping, has examined the brain effects of the psychedelic chemical in magic mushrooms, called psilocybin, using data from brain scans of volunteers who had been injected with the drug.
The study found that under psilocybin, activity in the more primitive brain network linked to emotional thinking became more pronounced, with several different areas in this network - such as the hippocampus and anterior cingulate cortex - active at the same time. This pattern of activity is similar to the pattern observed in people who are dreaming. Conversely, volunteers who had taken psilocybin had more disjointed and uncoordinated activity in the brain network that is linked to high-level thinking, including self-consciousness.
Psychedelic drugs are unique among other psychoactive chemicals in that users often describe ‘expanded consciousness,’ including enhanced associations, vivid imagination and dream-like states. To explore the biological basis for this experience, researchers analysed brain imaging data from 15 volunteers who were given psilocybin intravenously while they lay in a functional magnetic resonance imaging (fMRI) scanner. Volunteers were scanned under the influence of psilocybin and when they had been injected with a placebo.
“What we have done in this research is begin to identify the biological basis of the reported mind expansion associated with psychedelic drugs,” said Dr Robin Carhart-Harris from the Department of Medicine, Imperial College London.  “I was fascinated to see similarities between the pattern of brain activity in a psychedelic state and the pattern of brain activity during dream sleep, especially as both involve the primitive areas of the brain linked to emotions and memory. People often describe taking psilocybin as producing a dream-like state and our findings have, for the first time, provided a physical representation for the experience in the brain.”    
The new study examined variation in the amplitude of fluctuations in what is called the blood-oxygen level dependent (BOLD) signal, which tracks activity levels in the brain. This revealed that activity in important brain networks linked to high-level thinking in humans becomes unsynchronised and disorganised under psilocybin. One particular network that was especially affected plays a central role in the brain, essentially ‘holding it all together’, and is linked to our sense of self.
In comparison, activity in the different areas of a more primitive brain network became more synchronised under the drug, indicating they were working in a more co-ordinated, ‘louder’ fashion. The network involves areas of the hippocampus, associated with memory and emotion, and the anterior cingulate cortex which is related to states of arousal.
Lead author Dr Enzo Tagliazucchi from Goethe University, Germany said: “A good way to understand how the brain works is to perturb the system in a marked and novel way. Psychedelic drugs do precisely this and so are powerful tools for exploring what happens in the brain when consciousness is profoundly altered. It is the first time we have used these methods to look at brain imaging data and it has given some fascinating insight into how psychedelic drugs expand the mind. It really provides a window through which to study the doors of perception.”
Dr. Carhart-Harris added: “Learning about the mechanisms that underlie what happens under the influence of psychedelic drugs can also help to understand their possible uses. We are currently studying the effect of LSD on creative thinking and we will also be looking at the possibility that psilocybin may help alleviate symptoms of depression by allowing patients to change their rigidly pessimistic patterns of thinking. Psychedelics were used for therapeutic purposes in the 1950s and 1960s but now we are finally beginning to understand their action in the brain and how this can inform how to put them to good use.”
The data was originally collected at Imperial College London in 2012 by a research group led by Dr Carhart-Harris and Professor David Nutt from the Department of Medicine, Imperial College London. Initial results revealed a variety of changes in the brain associated with drug intake. To explore the data further Dr. Carhart-Harris recruited specialists in the mathematical modelling of brain networks, Professor Dante Chialvo and Dr Enzo Tagliazucchi to investigate how psilocybin alters brain activity to produce its unusual psychological effects.
As part of the new study, the researchers applied a measure called entropy. This was originally developed by physicists to quantify lost energy in mechanical systems, such as a steam engine, but entropy can also be used to measure the range or randomness of a system. For the first time, researchers computed the level of entropy for different networks in the brain during the psychedelic state. This revealed a remarkable increase in entropy in the more primitive network, indicating there was an increased number of patterns of activity that were possible under the influence of psilocybin. It seemed the volunteers had a much larger range of potential brain states that were available to them, which may be the biophysical counterpart of ‘mind expansion’ reported by users of psychedelic drugs.
Previous research has suggested that there may be an optimal number of dynamic networks active in the brain, neither too many nor too few. This may provide evolutionary advantages in terms of optimising the balance between the stability and flexibility of consciousness. The mind works best at a critical point when there is a balance between order and disorder and the brain maintains this optimal number of networks. However, when the number goes above this point, the mind tips into a more chaotic regime where there are more networks available than normal. Collectively, the present results suggest that psilocybin can manipulate this critical operating point.
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the-exercist:

Running Mix
Each song on this running playlist clocks in at 160 beats per minute, helping you stay on track for a 9:00 minute mile. This particular mix is made up of a balance between rock, alternative and pop songs.
"Hey Ya" by Outcast
"Oh My God" by The Cults
"Paint it Black" by The Rolling Stones
"I Saw Her Standing There" by The Beatles
"Goodbye to You" by The Veronicas
"It’s Only Me" by The Barenaked Ladies
"Some Girls Are Bigger Than Others" by The Smiths
"Pretty Girl Rock" by Keri Hilson
"Kinds in America" by Kim Wilde
"Hard to Explain" by The Strokes
"It’s a Hit" by We Are Scientists
"One Way of Another" by Blondie
"Run Right Back" by The Black Keys
"You Can’t Simi" by Houston Calls
"Awake and Alive" by Skillet
"All I Want" by A Day to Remember
Total time = 54 min
Click here to visit 8tracks and hear the mix. 
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tobiasxva:

undeadsidhe-inthetardis:

yeahwriters:

cleverhelp:

Write Rhymes finds rhymes for your words while you write and takes the weirdness out of poetry and scheming. 

Coooool!

I DON’T THINK YOU UNDERSTAND JUST HOW AMAZING THIS IS FOR WRITERSLIKEWE SPEND YEARS FILLING NOTEBOOKS WITH RHYMES FOR WORDS AND PHRASES AND END-RHYMES AND SLANT RHYMES AND THEN ONE DAY SOME 
FUCKING
GENIUS
GOES 
"YOU KNOW WHAT’D BE COOL?  MAKING EVERY POET WET THEMSELVES WITH FUCKING JOY”
I” M SO FUXKC I NG

Where was this when I was in high school?  :(
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neurosciencestuff:

(Image caption: Whole brain functional connectivity between the nucleus accumbens (NAc) and other brain areas in response to cannabis cues (vs. neutral cues) in all participants)
Dependence Alters the Brain’s Response to Pot Paraphernalia
New research from The University of Texas at Dallas demonstrates that drug paraphernalia triggers the reward areas of the brain differently in dependent and non-dependent marijuana users.
The study, published July 1 in Drug and Alcohol Dependence, demonstrated that different areas of the brain activated when dependent and non-dependent users were exposed to drug-related cues.
The 2012 National Survey on Drug Use and Health shows marijuana is the most widely used illicit drug in the United States. According to a 2013 survey from the Pew Research Center, 48 percent of Americans ages 18 and older have tried marijuana. The National Institute on Drug Abuse says that 9 percent of daily users will become dependent on marijuana.
“We know that people have a hard time staying abstinent because seeing cues for the drug use triggers this intense desire to seek out the drugs,” said Dr. Francesca Filbey, lead author of the study and professor at the Center for BrainHealth in the School of Behavioral and Brain Sciences. “That’s a clinically validated phenomenon and behavioral studies have also shown this to be the case. What we didn’t know was what was driving those effects in the brain.”
To find this effect, Filbey and colleagues conducted brain-imaging scans, called functional magnetic resonance imaging (fMRI), on 71 participants who regularly used marijuana. Just more than half of those were classified as dependent users. While being scanned, the participants were given either a used marijuana pipe or a pencil of approximately the same size that they could see and feel.
A comparison of the images revealed that the nucleus accumbens, the reward region in the brain, was activated in all users in response to the pipe. However, the strengths of the connections with other areas differed between dependent and non-dependent users.
“We found that the reward network is actually being driven by other areas unrelated to reward, like the areas in memory and attention or emotion,” Filbey said.
Non-dependent users showed greater activations in the orbital frontal cortex and hippocampus, suggesting that memory and attention were connected to the activation of the reward network. Dependent users had greater activations in the amygdala and anterior cingulate gyrus, suggesting a more emotional connection.
Additionally, the areas of the brain activated resemble areas activated for other addictions, such as nicotine or cocaine, lending greater support to the addictiveness of marijuana.
These findings suggest that marijuana abuse intervention needs to cater more specifically to a user’s level of addiction.
"Clinicians treating people with problems with marijuana dependence should consider the different processes that trigger the reward response when determining possible pharmacological or behavioral interventions,” Filbey said.